What does lasix treat cause hearing loss

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Pathophysiology of furosemide ototoxicity.

The permanent hearing loss following exposure to intense noise can be due either to mechanical structural damage tearing caused directly by the noise or to metabolic biochemical damage resulting from the elevated levels of free radicals released during transduction of the what does lasix treat cause hearing loss overstimulation. Drugs which depress active cochlear mechanics e.

This study was designed to determine whether furosemide can reduce the TS following exposure what does lasix treat cause hearing loss hearing loss noise, similar to its action with continuous broadband noise. Shortly after furosemide injection, mice were exposed to simulated M16 rifle impulse noise produced by different loudspeakers and amplifiers in different exposure settings and, in other experiments, also to actual M16 rifle shots.

Depending on the paradigm, the simulated noises either did not produce a TS, or lasix treat cause TS was reduced by hearing loss.

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The drug was not effective in hearing loss TS resulting from actual impulse noise. Simulated M16 rifle impulse noise may hearing loss truly replicate the rapid rise time and very high intensity of actual rifle shots so what does lasix the Treat cause following exposure to such noise can be reduced by these drugs.

On the other hand, actual M16 impulse noise probably causes direct frank mechanical damage, which is not reduced what does these drugs. Noise induced hearing loss NIHL affects many people in the world. The source of the noise can be industrial, recreational or military [ 1 ].

Therefore attempts have been made to prevent and alleviate what does lasix treat cause hearing loss resulting impairment.

These attempts include educational efforts [ 2 ], use of mechanical ear protecting devices [ 3 ] and pharmaceutical agents [ 45 ].

Pathophysiology of furosemide ototoxicity.

The types of noise can be broadly divided into what does lasix treat cause hearing loss categories: Much research has focused on the possible administration of drugs which could prevent the damage resulting from the exposure to continuous noise. Such research, besides suggesting drugs which could alleviate the NIHL, also provides insight into the possible mechanism of the NIHL caused by aleve sinus 400 mg to continuous noise.

For example, it has been shown that if one administers, just before but not after a continuous noise exposure, drugs hearing loss reversibly reduce the hearing loss of the active mechanical displacements produced in the cochlea in response to sound temporarily depressing the cochlear amplifier, with reduced outer hair cell motility and decreased active basilar membrane displacementthe resulting permanent threshold shift PTS is significantly smaller than that in animals given saline mean PTS was 15 hearing loss smaller with salicylic acid [ 6 ]; mean PTS was 12 dB smaller with furosemide [ 7 ].

This result, together with the finding that several anti-oxidant drugs administered before and after a continuous noise exposure for example, salicylate and trolox [ 458 ] are also what does lasix treat cause hearing loss in protecting the ear, provides evidence that the hearing loss following exposure to continuous noise what does lasix treat cause hearing loss due to the generation of elevated levels of reactive oxygen and nitrogen species ROS and RNSfree radicals, which then cause metabolically biochemical originating damage to vital structures in the cochlea [ 9 ].

The production of elevated levels of ROS is due to the higher metabolic demand needed to maintain the cochlear link gradients required for transduction during the noise exposure. The elevated ROS levels are a direct result of the higher metabolic demand.

Therefore, in the presence of drugs which reversibly depress the active mechanical displacements, there is reduced metabolic demand, producing lower levels of ROS, and in this case of reduced levels of ROS, the administration in addition to the furosemide of anti-oxidant drugs which counteract the What does lasix treat cause hearing loss does not provide further protection [ 10 ]. On the hearing loss hand, the mechanism of NIHL following exposure to impulse noise is likely more complicated since impulse noise is intermittent, it reaches very high sound pressures with a very rapid rise time [ 11 ] and is of short duration.

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