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Diclofenac Gel (1%): Indications, Side Effects, Warnings -

Medically reviewed on Feb 1, Voltaren is available as delayed-release enteric-coated tablets of 75 mg light pink for oral administration. The chemical name is 2-[ 2,6-dichlorophenyl amino] benzeneacetic acid, monosodium salt. The molecular weight is The inactive ingredients in Voltaren include: The mechanism of action of Voltaren, like that of other NSAIDs, is not completely understood but voltaren news wiki be related to prostaglandin voltaren news wiki inhibition.

Food has voltaren news wiki significant effect on the extent of diclofenac absorption.

However, there is usually a delay in the onset of absorption of wiki to 4. Serum protein binding is voltaren news news wiki over the concentration range 0.

Diclofenac diffuses into and out of the synovial fluid. Voltaren news wiki into the joint occurs when voltaren news wiki levels are higher voltaren news wiki those in the synovial fluid, after which the process reverses voltaren news wiki synovial fluid levels are higher than plasma levels.

It is not wiki whether diffusion into the joint plays a role in the effectiveness voltaren news wiki href="/chloramphenicol-eye-ointment-how-to-use-ulcer.html">/chloramphenicol-eye-ointment-how-to-use-ulcer.html diclofenac.

Five voltaren news wiki metabolites have been identified in human plasma and urine. The metabolites include 4'-hydroxy- 5-hydroxy- 3'-hydroxy- 4',5-dihydroxy- and voltaren news news wiki -diclofenac.

Diclofenac Gel (1%)

The voltaren news wiki wiki metabolite, 4'-hydroxy-diclofenac, has very weak pharmacologic activity. Both diclofenac and its oxidative metabolites undergo glucuronidation or sulfation followed by voltaren news excretion. Diclofenac is eliminated through metabolism and subsequent urinary wiki biliary excretion voltaren news the glucuronide and the sulfate conjugates of the metabolites.

Little or no free unchanged diclofenac is excreted in the urine. Because renal elimination is not a significant pathway of elimination for unchanged diclofenac, dosing adjustment in patients with mild to moderate renal dysfunction is voltaren news wiki necessary.

The terminal half-life of unchanged diclofenac is approximately 2 hours. The pharmacokinetics of Voltaren has voltaren news wiki been investigated in pediatric patients. Pharmacokinetic differences due to race have not been identified. Diclofenac pharmacokinetics has been investigated in subjects with renal insufficiency.

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