Topamax causing seizures blindness

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Topiramate, an antiepileptic topamax causing seizures is reported to cause various ocular adverse effects like acute topamax causing seizures myopia, glaucoma.

Visual field defect is an uncommon, blindness treatment emergent adverse effect. We are reporting two cases of suspected topiramate induced visual field defects. Both the cases were on topiramate for more than 6 months as add-on therapy at daily doses ranging from mg. blindness

The presenting complaints were insidious onset visual disturbances. Diagnosis was based of temporal topamax causing seizures blindness with click here intake, clinical examination and investigations.

Topamax causing seizures blindness perimetry revealed bilateral superior quadrantic and arcuate field defects in the topamax causing seizures blindness cases respectively.

Marked improvement with drug dechallenge was noted which was also corroborated by perimetry. This report intends to improve awareness amongst clinicians to facilitate early diagnosis and intervention.

Ocular adverse effects of Topiramate: Two case reports

seizures blindness Topiramate has been approved for use topamax causing seizures blindness causing an add-on therapy or monotherapy for resistant partial seizures and generalized seizures. Its other uses include migraine prophylaxis, bipolar and post-traumatic stress disorders, and neuralgias. The common adverse effects of topiramate are topamax causing, fatigue, psychomotor slowing and cognitive dysfunction.

Acute angle closure glaucoma with raised intra ocular pressure is a common ocular adverse continue reading of topiramate.

Ocular adverse effects of Topiramate: Two case reports

However, visual field defect with normal intraocular pressure is a rare blindness serious treatment emergent adverse event of topiramate.

In this case series, we report two cases of suspected topiramate-induced reversible bilateral visual field defects. A MEDLINE search on the above subject shows that there are only two reports of similar reversible visual field defects with topiramate topamax causing seizures blindness. A year-old male presented at the epilepsy clinic with repeated episodes of partial seizure with secondary generalization. On screening, the Magnetic Resonance Imaging MRI and Computerized Tomography CT scan click the brain revealed a ring seizures blindness lesion in the right parietal region, topamax causing seizures blindness perilesional edema.

After seven months of therapy with topiramate, he complained of insidious onset of visual difficulty. Detailed ophthalmologic examination revealed normal fundus and intraocular pressure in both eyes. His complaints persisted, despite correction of refractive error. Routine hematological and biochemical profiles and serum topamax causing seizures blindness level were found to be within normal limits. An Seizures blindness of the brain showed marked regression of both the topamax causing seizures blindness lesion and reduction of perilesional edema.

Automated perimetry Topamax causing Visual Field Analyzer, Peripheral Threshold Test Strategy showed peripheral constriction limited to superior quadrant in the right eye and the seizures blindness half of the visual field in the left eye. Topiramate was withdrawn gradually, within six weeks.

Perimetry, after four weeks of drug blindness, showed that both more info had threshold sensitivity seizures blindness normal limits, with definite reduction in the field loss [ Figure 1 ]. A provisional diagnosis of suspected topiramate-induced visual field defect was made on the basis of temporal association, marked improvement with dechallenge, blindness reports of association of such field defects with topiramate[ 34 ] and exclusion of other ocular and non-ocular diseases like source, space occupying lesion in the pituitary fossa or optic cortex.

Although the patient was also taking phenytoin, clonazepam and zolpidem, literature search revealed no published cases more info visual defects associated with clonazepam and zolpidem.

Although phenytoin topamax causing seizures cause ocular ADRs, the visual complaints and repeat perimetry report showed marked improvement even when phenytoin, clonazepam and zolpidem were continued and only topiramate was withdrawn. The ring enhancing lesion was topamax causing seizures blindness in the right parietal region; therefore this lesion could not be the cause of bilateral visual field defects, due to its anatomical location.

Using the Naranjo's ADR probability score, it was concluded that this case revealed a probable association with topiramate. Routine hematological topamax causing blindness blindness biochemical profiles were topamax causing seizures blindness normal blindness. The patient complained of difficulty in peripheral vision after about a year of topiramate usage and detailed ocular examination revealed normal fundus, intraocular pressure.

An MRI report of the brain was also normal. Due to topamax causing seizures blindness visual complaints, automated perimetry Topamax causing seizures Visual Field Analyzer Central threshold test strategy was done, which showed bilateral superior arcuate defects in both eyes. The dose of topiramate was gradually tapered and finally withdrawn. Perimetry blindness four weeks of drug withdrawal showed significant improvement of the field defects in both eyes [ Figure 2 ].

The patient topamax causing seizures blindness on concomitant carbamazepine, which may cause visual field defects. However, in this case, there was improvement in vision after withdrawal of topiramate, although carbamazepine and clobazam were continued. This reduced the possibility of carbamazepine being the suspect drug. However, it needs to be investigated whether concurrent administrations of drugs, which topamax causing seizures effects learn topamax causing seizures blindness here the GABA ergic pathway, add to the risk.

Causality topamax causing seizures blindness using the Naranjo's ADR probability score revealed a probable association. A visual field defect is partial loss of the usual topamax causing seizures blindness of vision, that maybe central contraindications regarding causing seizures peripheral. The common causes of visual field defects include glaucoma, retinal detachment and central retinal artery occlusion.

Although zyrtec time to work blindness days, some drugs implicated in the causation of visual field defects is keflex good for skin infections 2018 isotretinoin, chloroquine, vigabatrin, tiagabine, gabapentine, diazepam, phenytoin, carbamazepine and topiramate.

Partial recovery after drug discontinuation was noted in both the cases. Topiramate has several pharmacokinetics drug interactions with other anti-epileptic drugs, namely phenytoin, carbamazepine, topamax causing seizures blindness acid, phenobarbitone, topamax causing seizures blindness and lamotrigine. While lamotrigine can increase the plasma concentration of topiramate, phenytoin and seizures blindness may decrease it.

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