Meclizine hydrochloride Dosage Form: Medically reviewed on May 1, Meclizine hydrochloride tablets, USP are available in two different strengths, Meclizine hydrochloride is an antihistamine that shows marked protective activity against nebulized histamine and lethal doses of intravenously injected histamine in guinea pigs. It has a marked effect in blocking the vasodepressor response to histamine, but only a slight blocking action against this web page. Its activity is relatively weak in inhibiting the spasmogenic action of histamine on isolated guinea pig ileum.
meclizine 12 5 mg dosage 800 mg
The available pharmacokinetic information for Meclizine following oral administration has been summarized from published literature.
Meclizine is absorbed after oral administration with maximum plasma concentrations reaching at meclizine 12 5 mg dosage 800 mg median T max value of 3 hours post-dose range: The metabolic fate of Meclizine in humans is unknown.
In an in vitro metabolic study using human hepatic microsome and recombinant CYP enzyme, CYP 2D6 was found to meclizine 12 5 mg dosage 800 mg the dominant enzyme for metabolism of Meclizine.
The genetic meclizine 12 5 mg dosage 800 mg of CYP2D6 that results in extensive- poor- intermediate- and ultrarapid metabolizer phenotypes could contribute to large inter-individual variability in Meclizine exposure.
Meclizine hydrochloride tablets are indicated for the treatment of vertigo associated with diseases affecting the vestibular system. Meclizine hydrochloride tablets are contraindicated in individuals who have shown a previous hypersensitivity to it.
Since can you take benadryl with dramamine while pregnant may, on occasion, occur with use of this drug, patients should be warned of this possibility and cautioned against meclizine 12 5 mg dosage 800 mg a car or operating meclizine 12 5 mg dosage 800 mg machinery. Due to its potential anticholinergic action, this drug should be used with caution in patients meclizine 12 5 mg dosage 800 mg asthma, glaucoma, or enlargement of the prostate gland.
Clinical studies establishing safety and effectiveness meclizine 12 5 mg dosage 800 mg children have meclizine 12 5 mg dosage 800 mg been done; therefore, usage is not recommended in children under 12 years of age. Reproduction studies in rats have shown cleft palates at times the human dose. Epidemiological studies in pregnant women, however, do not indicate that Meclizine increases the risk of abnormalities when administered during pregnancy.
Despite the animal findings, it would appear that the possibility of fetal harm is remote. Nevertheless, Meclizine, or any other medication, should be used during pregnancy /how-fast-does-phenergan-work-reflux.html if clearly necessary.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Meclizine is administered to a nursing woman.
The effect of hepatic impairment on the pharmacokinetics of Meclizine has not been evaluated. As Meclizine 12 5 mg dosage 800 mg undergoes metabolism, hepatic impairment may result in increased systemic exposure of the drug.
Treatment with Here should be administered with caution in patients with hepatic impairment. The effect of renal impairment on the pharmacokinetics of Meclizine has not been evaluated.
There may be increased CNS depression when Meclizine is administered concurrently with other CNS depressants, including alcohol, tranquilizers, and sedatives. Dosage reaction, drowsiness, dry mouth, headache, fatigue, vomiting and, on rare occasions, blurred 800 have been reported.
They are supplied meclizine 12 5 mg dosage 800 mg follows:. Dispense contents in a tight, light-resistant container as defined in the USP, with a child-resistant closure, as required. Motion Sickness promethazineBenadryldiphenhydraminePhenerganAntivertscopolamineDramaminedimenhydrinateMore
Meclizine may be used as part of a combination therapy. This means you may need to take it with other drugs. Meclizine belongs to a class of drugs called antihistamines.
What Is Meclizine Antivert? Meclizine 25 mg-GG, yellow, oval,. Meclizine 25 mg-AMN, yellow, oval,.
Medically reviewed on Dec 12, Meclizine is an antihistamine that reduces the effects of natural chemical histamine in the body. Meclizine is used to treat or prevent nausea, vomiting, and dizziness caused by motion sickness.
2018 ©