Januvia kidney disease guidelines

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Three-year safety outcomes with sitagliptin Disease guidelines in patients with type 2 diabetes januvia kidney chronic kidney disease CKD were no here than with placebo, according to data from a large cardiovascular outcomes trial.

While diabetic patients with januvia kidney guidelines tended to fare worse overall than their counterparts without CKD, use of januvia kidney disease guidelines was well tolerated in this patient population and raised no safety concerns, disease guidelines researchers led by Samuel Engel, MD, disease guidelines Merck Research Laboratories in Kenilworth, N.

However, among CKD patients only, those on sitagliptin had no significantly increased risk for all disease guidelines adverse events compared with those on placebo RD Sitagliptin is a dipeptidyl peptidase-4 DPP-4 inhibitor, a class of drugs that works by prolonging the action of disease guidelines incretin hormones glucagon-like peptide-1 GLP-1 and glucose-dependent insulinotropic peptide GIPleading to improved glycemic control, the investigators explained.

The TECOS trial enrolled more than 14, participants with type 2 diabetes and at risk for cardiovascular disease.

TECOS: Sitagliptin Safe in CKD Patients

Of these patients, more than 3, also had CKD. Patients were januvia kidney disease guidelines 50 or older; had atherosclerotic cardiovascular disease; and had glycated hemoglobin values of 6.

Patients were randomized to sitagliptin or placebo and followed for a median of 2. Engel and colleagues compared safety data in the cohort januvia kidney disease guidelines patients with CKD versus those without, and disease guidelines compared safety data in patients with CKD assigned to sitagliptin or placebo.

A review of sitagliptin with special emphasis on its use in moderate to severe renal impairment

Key results see more the analysis in patients with CKD included the following: The most common serious adverse event were neoplasms, which occurred in 4. While the estimated glomerular filtration rate eGFR declined modestly in both the treatment and januvia kidney groups, the decline was slower in the sitagliptin group, with a statistically significant difference of Finally, this analysis of safety data did not include the disease guidelines endpoints of the main trial.

Treatment with sitagliptin was generally well disease guidelines with no meaningful differences observed in safety januvia kidney disease guidelines between those with CKD assigned sitagliptin januvia kidney disease guidelines placebo," disease guidelines investigators concluded. The Best Nursing Apps of What We Heard This Week.

Note januvia kidney this secondary analysis of a januvia kidney disease guidelines trial evaluating sitagliptin for the treatment of diabetes found that the drug did not lead to higher adverse januvia kidney disease compared with placebo among patients with chronic januvia kidney disease guidelines disease CKD.

Overall, those here CKD randomized to the sitagliptin arm had a significantly reduced rate of decline of guidelines glomerular filtration rate. Engel SS et al "Safety of sitagliptin in patients with type 2 diabetes and chronic kidney disease:

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