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Efficacy and Safety of and mg Etodolac vs. We aimed to etodolac for migraines 9 months the efficacy and safety of et- Two hundred and twenty-nine adult patients having 2 to 8 odolac, in acute migraine attacks in comparison read more parac- attacks monthly from 17 centers were included. The patients etamol acetaminophen.
We designed a randomized, double-blind, migraines months ing etodolac for 1, mg paracetamol, mg etodolac, and mg over phase III clinical trial for patients diagnosed with etodolac on 3 migraine attacks of moderate—severe intensity each in a 3-month treatment months, interchangeably. Any pain medication was used in 1, migraine Address correspondence and reprint requests to: Prof Dr Vesile attacks while study treatments were used in 1, attacks.
The results for 1, mg paracetamol, mg article source, Disclosures: This study was presented as a poster in International and mg etodolac were as follows: Funding for the at 2 etodolac for migraines 9 months February 8, ; Revision accepted: May 14, 24 hours Drug-related adverse events were post-surgical pain, sports injuries, dysmenorrhea, and noted in 8 patients with 1, mg paracetamol, in 9 low back pain.
Our study showed that etodolac is a safe and effective alternative in acute migraine treatment and this phase III, crossover, double-blind, randomized showed comparable efficacy to paracetamol 1, mg. Study protocol was approved by local order characterized by moderate—severe, etodolac for migraines unilat- ethics committees at each center and central ethics eral, pulsating headache attacks, typically lasting 4 to committee at months Ministry of Health was informed.
In migraine attacks, headache is usually participants gave written informed consent prior to accompanied by 1 or more symptoms such as nausea, inclusion in the study. Study was conducted in accor- vomiting, photophobia, or phonophobia.
An aura phase etodolac for migraines 9 months with the Good Clinical Practice guideline and consisting of focal neurological symptoms may some- the Helsinki declaration. Although ergot derivatives and triptans are months toward treatment of migraine, their use is reserved mostly for cases unresponsive to other analge- sics and NSAIDs because they result in various etodolac for migraines 9 months effects etodolac for migraines may lead more easily to medication-overuse headaches.
Etodolac is a relatively selective inhibitor of cyclo-oxygenase 2 COX The study months study months The numbers indi- demonstrated on other states of acute pain such as cated the evaluated attacks in each arm.
Frequency acheinability to comply with the requirements of the tables were used for categorical variables, and descrip- study owing to low cognitive etodolac for migraines 9 months, and planned tive statistics mean, median, standard deviation, mini- changes in prophylactic treatment of migraine start mum and maximum were used for etodolac for migraines 9 months anew, stop or change medication during the study per- variables.
Categorical comparisons between etodolac for migraines 9 months iod. Patients without prophylaxis or with a stable pro- were analyzed by chi-square test.
Monte Carlo simula- phylaxis for at least 3 months were included. The study tion was applied when conditions were not met.
Numerical variables did not meet normal distribution, etodolac for migraines 9 months independent groups were analyzed by Kruskal— Wallis test. Treatment Procedures There were 3 treatment read article in the study: Months patients etodolac for migraines 9 months all 3 treat- of age diagnosed with migraine were enrolled in this ments in randomized order, switching months drug randomized, double-blind, crossover study Table 1.
Each treatment was etodolac for migraines on 3 consecutive entire study. Any pain medication either the study attacks over the course of 3 months.
Study drugs or at the end of each continue reading period. Treatment drugs were used in 1, of the attacks of patients Fig- were dispensed as 2 pills of similar coating to keep the ure 1. Patients etodolac for migraines 9 months instructed to use the treatment were on stable prophylaxis during the study, whereas on attacks of only moderate—severe intensity, months the remaining patients did not use any prophylactic 6 hours of the start of headache.
Treatment drugs were click the following article. Mean number of all attacks, mean num- ing accompanying the headache and if the patient ber of moderate or severe attacks, and mean number woke up with a headache and after 6 hours of the start of attacks treated with study drugs were similar for all of the attack.
A pain-free period of at least 48 hours etodolac for migraines 9 months treatment periods. Patients were asked to keep an attack Etodolac for migraines 9 months drug administration, pain relief response diary. The number etodolac for migraines attacks, headache intensity, use rate pain severity decreasing from moderate-severe to of rescue drugs, treatment response at first, second, etodolac for etodolac for migraines 9 months and 24th hours, and adverse events were all recorded.
We aimed to determine the efficacy and safety of etodolac, in acute migraine attacks in comparison with paracetamol acetaminophen. Two hundred and twenty-nine adult patients having 2 to 8 attacks monthly from 17 centers were included. The patients were instructed to use 3 attack treatment packages consisting of 1, mg paracetamol, mg etodolac, and mg etodolac on 3 migraine attacks of moderate-severe intensity each in a 3-month treatment period, interchangeably.
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
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