Does periactin make you gain weight where does it go

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I have seen a female patient with recurrent spontaneous urticaria.

Periactin User Reviews for Anorexia at

Her urticaria is well responded to antihistamine, although not full control. However, she is experiencing a significant weight gain since she has been visit web page zyrtec.

Zyrtec was replaced with Allegra with no improvement. Secondary causes such as hypothyroid or cushing were ruled out. I have known that weight gain is a possible, although not very common, complication of antihistamine therapy but am aware that they might be just coexistence.

The problem is she realized that she needs to does periactin make you gain weight where does it go antihistamine to control her hives but was reluctant to increase the dose. She asked me to find an alternative or the antihistamine that has least effect of weight gain. Could you please give me some suggestions regarding this case?

Thank you for your inquiry.

Periactin and weight gain?

It has long been known that the administration of antihistamines can cause weight gain. In fact, one antihistamine, cyproheptadine, has been used for this purpose. There are many postulations as to why this occurs. One reason, which may be the most reasonable, is that histamine is known to reduce the where does, and antihistamines, therefore, counteract this effect.

Antihistamines and weight gain

They found, as in the Does periactin make you gain weight where does it go survey, that the use of over-the-counter antihistamines, including both fexofenadine and cetirizine, was associated with obesity. Unfortunately, we know more about this association and the potential underlying reasons for it than we do about which antihistamines may be less likely to produce this effect. I know of no study comparing does periactin make effects of available antihistamines on weight gain and could find none on a literature search.

Therefore, although it is not unlikely that some antihistamines may be more potent than others in this regard, the effect appears to be more class-related rather than drug-specific.

Periactin and weight gain?

But because we have no available information on relative potency of antihistamines regarding their article source on weight gain, there is, to my knowledge, no information available to assist you in selecting a specific antihistamine that might be helpful and does periactin make you gain weight where does it go produce this side effect.

A thorough discussion of these drugs are available in two articles. Morgan M and Khan DA. Annals of Allergy, Asthma, where does Immunology ; References and abstracts of references are copied below should you wish to read further about the issue of antihistamines and weight gain. Thank you again for your inquiry and we hope this response is helpful to you.

Obesity Volume 18, Issue 12, pages —, December Abstract The incidence of obesity in the United States has reached epidemic proportions. Previous research has see more several medications exert noticeable effects on body-weight regulation.

Histamine-1 H1 where does blockers commonly used to alleviate allergy symptoms are known to report weight gain as a possible side effect. Adults taking prescription H1 antihistamines were matched by age and gender with controls and compared on the basis of body measurements, plasma glucose, insulin concentrations, and lipid levels. Prescription H1 antihistamine users had a where does higher weight, waist circumference, and insulin concentration than matched does periactin make you gain weight where does it go.

The odds ratio OR for being overweight was increased where does prescription H1 antihistamine users.

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H1 antihistamine use may contribute to the increased prevalence of obesity and click here metabolic syndrome in adults given these medications are also commonly used as over-the-counter remedies. Epub Nov Potential benefits of cyproheptadine in HIV-positive patients under you gain weight with antiretroviral drugs including efavirenz.

Dizziness, headache, nightmares, abnormal dreams, mild cognitive difficulty, sleep disturbance somnolence and insomniaimpaired concentration, depression, hallucination, delusion, paranoia, anxiety, agitation, aggressive behavior, mania, emotional labiality, catatonia, melancholia, psychosis, and fatigue are the most reported efavirenz adverse does periactin make you gain weight where does it go. The available evidence was collected by searching Scopus, PubMed, Medline, Cochrane central register of controlled trials, and Cochrane database systematic reviews.

Cyproheptadine is a cheap and safe drug that does not have significant interactions with antiretroviral drugs. Cyproheptadine's common see more effects including increasing appetite and weight gain can be useful in HIV-positive individuals with their decreased appetite and weight click here. There is limited evidence regarding the effectiveness of cyproheptadine in neuropsychiatric disorders.

How to Take Periactin to Gain Weight

Neuronal histamine and its receptors: Masaki T, Yoshimatsu H. Abstract Obesity is the effect of imbalance between energy intake and expenditure and forms a fundamental basis of the metabolic syndrome. A number of substances implicated in the regulation of energy metabolism represent opportunities for anti-obesity drug development.

Neuronal histamine and its receptors have been shown to regulate energy metabolism and are considered as anti-obesity targets. Several histamine receptor subtypes have been identified; does periactin these, histamine H1 and H3 receptors H1-R and H3-R have been specifically recognized as mediators of energy intake and expenditure. In addition, several histamine drugs related to Make you and H3-R, have been shown to attenuate body weight gain both in rodent and human.

These results provide the reagents for histamine receptors gain weight where and may find applications in the treatment of obesity and related metabolic disorders.

In this review, the development of does and antagonists of histamine receptors does periactin make you gain weight where does it go provided.

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