Does olanzapine make you gain weight or lose weight

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Antipsychotics are effective for treating schizophrenia, but atypical antipsychotics can cause several adverse side effects including weight gain, hyperprolactinemia, and extrapyramidal symptoms.

Moreover, weight gain increases the risk of metabolic diseases. We treated a case of olanzapine-induced weight gain in a year-old man with schizophrenia by switching his medication from olanzapine to asenapine.

Weight gain with olanzapine: Drug, gender or age?

The weight gain improved after switching the medication, from Asenapine might be effective for treating patients with schizophrenia who experience olanzapine-induced weight gain. Schizophrenia is mainly treated with antipsychotics, 5 which block dopaminergic, histaminergic, serotonergic, cholinergic, and alpha-adrenergic receptors. Their strong affinities for these receptors affect both positive and negative symptoms. Does does olanzapine make you gain weight or lose weight make you gain weight or lose weight antipsychotics AAPs are effective for treating schizophrenia please click for source have fewer side effects than typical antipsychotics, 6 but they can still cause extrapyramidal symptoms, 7 hyperprolactinemia, 8 sedation, 9 and weight gain.

Previous studies have shown that it carries a lower risk of weight gain than olanzapine.

A year-old man with schizophrenia began experiencing auditory hallucinations when he was 19 years old, but had only been prescribed antipsychotics after being hospitalized for worsening psychosis when he was 29 years old.

After the hospitalization, he was referred to our hospital, but he did not consistently adhere to treatment, so his psychosis exhibited cyclical remissions and relapses.

Does olanzapine make you sleepy, and gain weight?

When he was 41 years old, auditory hallucinations and delusions of persecution caused him does olanzapine make you gain weight or lose weight refuse food despite being prescribed quetiapine, so he was again referred to our hospital. He weighed 56 click here and had a body mass index BMI of He did not have a does olanzapine make you gain weight or lose weight of other comorbid medical illness.

The patient was diagnosed with schizophrenia according to the criteria in the Diagnostic and Statistical Manual of Mental Disorders5th Edition.

Although he experienced markedly reduced psychosis, olanzapine-induced overeating increased his weight to At this point, he did not appear to have any physical illness such as diabetes, dyslipidemia, or hypertension. His overeating does olanzapine make you gain weight or lose weight within a week after does olanzapine make you gain weight or lose weight tapering had ended without exacerbation of psychosis.

Over the following 1 year, the dose was maintained, his weight gain did not recur Importantly, he never received other interventions that could affect weight loss during the observation period, such as dietary counseling or changes in diet and exercise.

The patient was also taking benzodiazepines, but the quantity and types of benzodiazepines did not change during this period.

To the best does olanzapine make you gain weight or lose weight our knowledge, this case represents the first evidence that asenapine is an effective and well-tolerated therapy for improving olanzapine-induced weight gain without exacerbating psychotic symptoms.

AAPs increase the risk of weight gain 14 by blocking 5-HT 2C serotonin receptors and H 1 histamine receptors, with olanzapine carrying a particularly high risk. In a meta-analysis comparing antipsychotics, asenapine was no less effective than olanzapine for acute schizophrenia. However, it is important that the olanzapine dose be tapered because rapid withdrawal may trigger cholinergic withdrawal syndromes, such as agitation, headache, click at this /what-is-augmentin-used-for-toothache.html anxiousness, diarrhea, abdominal pain, and queasiness.

Weight gain with olanzapine: Drug, gender or age?

In this case report, only a 6. This case suggests that asenapine is an effective and well-tolerated treatment for antipsychotic-induced metabolic abnormalities in patients with does olanzapine make you gain weight or lose weight. This case suggests that asenapine might be an efficacious and well-tolerated treatment for olanzapine-induced weight gain does olanzapine make you gain weight or lose weight patients with schizophrenia.

Further studies with larger sample sizes are needed to validate the apparent does olanzapine make you gain weight or lose weight, safety, and tolerability of asenapine in this application. We would like to does olanzapine make you gain weight or lose weight the patient and his family for their cooperation.

As we encountered this case during regular clinical practice, the weight for ethics approval and consent was waived. We you gain written informed consent for the publication of this case does olanzapine make from the patient. Data sharing was lose weight applicable to this article as no datasets were generated or analyzed during the current study. This case report did not receive any specific read more from funding agencies in the public, commercial, or not-for-profit sectors.

KO collected data and wrote the first draft of the manuscript. KY and TK supervised the project, were critically involved in its design, and assisted in editing the final manuscript.

Does olanzapine make you sleepy, and gain weight?

All authors contributed toward data analysis, drafting and revising the paper and agree to be accountable for all aspects of the work. National Center for Biotechnology Does olanzapine make you gain weight or lose weight. Journal List Neuropsychiatr Dis Treat v.

Published online Nov Author information Copyright and License information Disclaimer. This work is published go here licensed by Dove Medical Press Limited. The full terms of this license are available at https:

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