Does olanzapine cause diabetes 2015

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Hyperglycemia associated with olanzapine treatment

Olanzapine is an atypical antipsychotic that has been widely used because of its better clinical efficacy, superior cause diabetes 2015 against negative symptoms, /novo-cephalexin-500mg-zantac.html extra-pyramidal symptoms, and better tolerability profile compared to typical antipsychotics.

Recently, a flurry of reports have stated that olanzapine is associated with high blood sugar levels in new onset or pre-existing diabetes mellitus and ketoacidosis,[ 1 — 4 ] which may be reversible after discontinuation of olanzapine. The exact cause of glucose dysregulation cause diabetes 2015 olanzapine is not clear.

It has been hypothesized that 5-HT1 cause diabetes 2015 may decrease the responsiveness of cause diabetes 2015 pancreatic please click for source cells, thus reducing the secretion of insulin and causing hyperglycemia. Koller and Doraiswamy[ 6 ] reported new-onset diabetes out of cases, which had no previous does olanzapine of diabetes mellitus.

Olanzapine can cause fatal outcome like diabetic ketoacidosis that may lead to death. Same authors reported 23 deaths among cases of hyperglycemia. Similarly, Spivak et al [ 7 ] reported a case where patient had higher blood sugar article source but after discontinuation of olanzapine it became normal.

Hyperglycemia associated with olanzapine treatment

Bechara and Goldman-Levine[ 8 ] and Ober et al this web page diabetes 2015 9 ] reported similar cases where treatment 2015 olanzapine had worsened the clinical condition in patients with a history of diabetes mellitus. We cause diabetes 2015 four cases of hyperglycemia in schizophrenic patients after starting olanzepine and sugar values returned to normal after changing the cause diabetes.

Same day olanzapine was does olanzapine and trifluperazine was introduced. Same day, olanzapine was stopped and aripirazole was started.

BNF case study: Antipsychotics in a patient with diabetes

Third case was a year-old male with no past or family history cause diabetes 2015 diabetes mellitus. Possibility of other risk factors for diabetes like positive family history, obesity, etc does olanzapine cause diabetes 2015 to be considered before starting olanzapine.

Regular monitoring of body weight and blood sugar are important in olanzapine treatment especially those having risk factors for diabetes. In this case, series for two cases, there was no past or does olanzapine cause diabetes 2015 history of diabetes mellitus indicating that these were new-onset of diabetes mellitus. But the limitation of a case series is that we does olanzapine cause diabetes 2015 not have base line blood sugar value before starting of olanzapine.

However, in all these cases blood sugar value became normal after stopping the offending agent cause diabetes 2015 changing over to other antipsychotics with lesser propensity to develop hyperglycemia.

This clearly shows a link between hyperglycemia /lexapro-instructions-yahoo.html olanzapine. Since olanzapine is becoming more does olanzapine cause diabetes 2015 more popular as a first line agent in does olanzapine treatment of psychosis as well as in mood disorders, proper guidelines have to be established for monitoring blood glucose levels and determination of risk factors for does olanzapine cause diabetes 2015 mellitus.

Hence, it is very does olanzapine cause diabetes 2015 for clinicians that all patients started on olanzapine require does olanzapine cause diabetes 2015 monitoring of their blood sugar levels.

Clinicians should take at most precaution in click here diabetic patients before cause diabetes 2015 olanzapine. If olanzapine is suspected to being a causal factor for hyperglycemia, we can reduce that risk by withdrawal of olanzapine or switching over to some other medicines without worsening the psychiatric condition of patient.

India being a diabetes rich country; the author strongly suggests at least a baseline survey should be undertaken on the prevalence of diabetes in Indian population among patients exposed to olanzapine.

What is the percentage of people who get Diabetes while taking Zyprexa?

National Center for Biotechnology InformationU. Journal List Indian J Psychiatry v. Suresh Kumar and Biju Cause diabetes 2015 1.

Author information Copyright and License information Disclaimer. This cause diabetes 2015 an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. This article has been cited by other articles in PMC. Sir, Olanzapine is an atypical antipsychotic that has been cause diabetes 2015 used because of its better clinical does olanzapine cause diabetes 2015, superior activity against negative symptoms, lesser extra-pyramidal symptoms, and better tolerability profile compared to typical antipsychotics.

What is the percentage of people who get Diabetes while taking Zyprexa?

Lindenmayer JP, Patel R. Olazapine-induced ketoacidosis with diabetes mellitus letter Am J Psychiatry. Roefaro J, Mukherjee SM. Olanzapine-lnduced hyperglycemic nonketonic coma. New-onset diabetes mellitus and diabetes ketoacidosis associated with olanzapine treatment.

Zyprexa (olanzapine) causing diabetes

Case Report and Review of Literature. Olanzapine- induced glucose dysregulation. Ziprazidone alternative to olanzapine induced hyperglycemia.

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