Bioequivalence evaluation of two formulations of fluconazole 150 mg capsule in healthy Arab men.

Skip arabic main content. Log In Sign Up. Bioequivalence evaluation of two formulations of fluconazole mg capsule in healthy Arab men. A randomized crossover study was conduaed on 26 healthy Arab males to compare the bioavailabiity diflucan 150 mg arabic two diflucan 150 mg arabic of fluconazole mg capsules, FluconazoleTM test and Diflucan reference.

The formulations were adminEstered after an overnight last with a washout period of 2 continue reading.

Twenty blood samples arabic period source collected over lash, plasma fluconazole concentrations were determined by locally validated high performance liquid chromatography HPLC assay and pharmacokinetic parameters were analysed by the standard non-cornpartmentnl method.

Further, a review of diflucan 150 mg arabic literDture indicates that there is no apparent ethnic variation In the absorption and eflmination rates of fluconazole.

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Bioequivalence studies Subjects and Methods are required by the Ministries of Health arabic tht Twuntv-eight arabic niedic-al histrny, clinical Gulf Cooperation Diflucan 150 mg arabic GCC counthes in order to register and market arabic drugs in the exalmnahon and roudne laboratory investigation GCC countries.

The aim of this study was to within 30 days /buy-benzac-online-10.html, diflucan 150 Arab males arabic enrolled compare the rate and extent of absorption of two in the study; one withdrew before starting, and another after completing, the first part of the snrdy, both for personal reasons. Centre fcr CLnica RecarcS. The volunteers were non-sine 1 Nxter 2G4 Rti,d 24rj2 5 h: The intra- and inter-day containing beverages or food fur 48h, and from arabic of variations diflucan 150 S.

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The quantification arabic throughout diflucan 150 study except for one volunteer was 0. None of the —20C. All diflucan 150 were analysed blindly within volunteers vomited and no adverse events were I month from collection, and after a single cycle identified except for bouts of arabic sinus of freeze and thaw.

They signed a Pharmacokinetic calculations were performed consent form that was approved by the Research according to the standard non-compartmental Ethics Committee of the King Faisal Specialist method. The study was crossover design was used to assess the effect of conducted according to the Declaration of diflucan 150 mg arabic, period, sequence and arabic nested Helsinki, Good Clinical Practice and Good in sequence on natural diflucan 150 data of Laboratory Practice guidelines.

Venous blood samples go here In addition, bioequivalence was assessed by collected in heparini2ed tubes, before and at 0.

Pharmacokinetic A high performance liquid chromatographic parameters are shown in Diflucan 150 mg arabic 1.

ANOVA assay was locally developed arabic validated. The hire on a Nova-Pak C 1 cartridge and detected absence of significant sequence or period effects spectrophotometrically at gm. The mobile suggests that the crossover diflucan 150 mg arabic was properly phase, 0.

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Concomitant drugs known to prolong the QT interval and metabolized by CYP3A4 eg, cisapride, astemizole, erythromycin, pimozide, quinidine. Monitor closely for skin rashes; discontinue if lesions progress. Renal or hepatic impairment.

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Drug information provided by: Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.