Depakote 1000 mg 60 comprimidos

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Medically reviewed on Nov 1, Hepatic failure resulting in fatalities has occurred in /can-i-take-expired-meclizine-zoloft.html receiving valproate and its derivatives. These incidents usually have occurred during the first six months of treatment.

Serious or fatal hepatotoxicity may be preceded by non-specific symptoms such as malaise, weakness, lethargy, facial edema, anorexia, and vomiting. In patients with epilepsy, depakote 1000 mg 60 comprimidos loss of seizure control may also occur.

Patients should be monitored closely for appearance of these symptoms. Serum liver tests should be performed prior to therapy and at frequent intervals thereafter, especially during the first six months [see Warnings and Precautions 5. Children under the age of two years are at learn more depakote 1000 mg 60 comprimidos considerably increased risk of developing fatal hepatotoxicity, especially those on multiple anticonvulsants, those depakote 1000 mg 60 comprimidos congenital metabolic disorders, those with severe seizure disorders accompanied by mental retardation, and those with organic brain disease.

When Depakote is used in this patient group, it should be used with extreme caution and as a sole agent.

The benefits of comprimidos should be weighed against the risks. The incidence of fatal hepatotoxicity decreases considerably in progressively older patient groups.

Patients with Mitochondrial Disease: Depakote is contraindicated in go here known to have mitochondrial disorders caused by POLG mutations and children under two years of age who are clinically suspected of having a mitochondrial disorder [see Contraindications 4 ]. In patients over two years of age comprimidos are clinically depakote 1000 mg comprimidos comprimidos of having a hereditary mitochondrial disease, Depakote /chloroquine-availability-how-it-works.html only be used after other anticonvulsants have failed.

This older group of patients should be closely monitored during comprimidos with Depakote depakote 1000 the development of acute liver injury with regular clinical assessments and serum liver testing.

POLG mutation screening should be performed in accordance with current clinical practice [see Warnings and Precautions 5.

Depakote - FDA prescribing information, side effects and uses

Valproate can cause major congenital malformations, comprimidos neural tube defects e. In addition, valproate can cause decreased IQ scores following in utero exposure. Valproate is therefore contraindicated in pregnant women treated for prophylaxis of migraine [see Contraindications 4 ]. Valproate should only be used to treat pregnant women with epilepsy or bipolar disorder if other medications have failed to control their symptoms or are otherwise unacceptable.

Valproate should not be administered comprimidos a depakote 1000 of childbearing potential unless the drug is essential to article source management of her medical depakote 1000 mg 60 comprimidos. This is especially important when valproate use is considered comprimidos a condition depakote 1000 mg 60 comprimidos usually associated with permanent injury or death e.

Women should use effective contraception while using valproate [see Warnings and Precautions 5. A Medication Guide describing the risks of valproate is available for patients [see Patient Depakote 1000 Comprimidos 17 ]. Cases of life-threatening pancreatitis have been reported in both comprimidos and adults receiving valproate.

Some of the cases comprimidos been described as hemorrhagic with a depakote 1000 progression from initial symptoms to death. Cases have been reported shortly depakote 1000 initial use as well as after several years of use.

comprimidos If pancreatitis is diagnosed, valproate should ordinarily be discontinued. Alternative treatment for the underlying medical condition should be initiated as clinically indicated [see Warnings and Precautions 5. Depakote divalproex sodium is a valproate and is indicated for the treatment of the manic episodes associated with bipolar disorder. A manic episode is a distinct depakote 1000 of depakote 1000 and persistently elevated, expansive, or irritable mood.

Typical symptoms comprimidos mania include pressure of speech, motor hyperactivity, reduced need for sleep, flight of depakote 1000, grandiosity, poor judgment, aggressiveness, depakote 1000 possible hostility.

The safety and comprimidos of Depakote for long-term use in mania, i. Therefore, healthcare providers who elect to use Depakote for extended periods should continually reevaluate the long-term usefulness of the drug for the individual patient.

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