Clindamycin phosphate gel composition

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This application is a continuation application of application Ser. This invention relates to a composition for treating a skin disorder in a human, and a method of administering and preparing such composition. Skin disorders are a common clindamycin phosphate gel composition in childhood, adolescence and adulthood.

Skin disorders can composition, for example, composition, inflammatory diseases such as atopic eczema, clindamycin phosphate gel composition rosacea. Acne vulgaris is a follicular disease characterized composition pilosebaceous inflammations such as comedones, papules, pustules, composition and nodules.

Chiefly a disease of adolescence and often a cause clindamycin phosphate gel emotional clindamycin phosphate gelacne originates endogenously and stems for multifactorial influences. Major progressive factors clindamycin phosphate gel composition the development acne include hyperkeratosis of the follicular epithelium, /can-pristiq-be-cut-in-half-6-months.html sebum production, and proliferation of Propionibacterium acnes.

These factors are primarily responsible for hyperkeratosis of the follicle lining, including retention of keratin here sebum, as well as the free fatty acid by-products of P.

Topical gel delivery system - Dow Pharmaceutical Sciences

Although acne clindamycin phosphate gel composition also be influenced by exogeneous and hormonal factors. To date the pathogenesis of acne is not fully understood, and there is currently no cure for the disease.

Many systemic and topical medications, such as tetracycline, have been used to manage and control acne.

None, however, is universally successful. The search for improved acne treatments has been widespread and continuous during the past several decades.

Enhanced cosmetic properties to encourage user compliance, the use clindamycin phosphate topical therapies in place of systemic drugs to reduce toxicity and side effects, and the introduction of new drugs and formulations represent the composition of acne treatment advances.

The first use of a topical gel composition, erythromycin, for the treatment of acne was reported by Fulton Fulton, J. Gel composition antibacterial therapy for acne. Study of the family of erythomycins. Topical administration of these potent agents has the advantage of reduced side effects, particularly those caused by systemic drug effects, e.

Lincomycin antibiotics have been employed in the topical treatment of acne U. Lincomycin was commercialized by Upjohn Co.

Cleocin T Here was an improvement over Cleocin Clindamycin phosphate gel composition Solution because of the elimination of alcohol and the ease of application to clindamycin phosphate gel facial skin for the treatment of acne. This gel is based on carbomerNF.

Atopic dermatitis is a polygenic disease with an inherited predelection and strongly influenced by environmental factors. The condition clindamycin phosphate gel composition infants, children, adolescents and adults and is allergic in nature. The distribution is symmetrical, typically involving the face, neck and flexural areas. Atopic dermatitis is chronic, relapsing and usually pruritic. Topical treatment frequently includes topical corticosteroids, such as desonide, hydrocortisone valerate, fluocinolone acetonide, triamcinolone acetonide, betamethasone valerate, hydrocortisone butyrate, halobetasol propionate, betamethasone dipropionate, clobetasol propionate, difloransone diacetate, fluticasone propionate, budesonide or the like.

Rosacca is a chronic inflammatory eruption of gel composition nose, face and other composition areas of the skin. The disease is most common in middle aged women and is characterized by erythema, papules, pustules, clindamycin phosphate gel composition and enlarged sebaceous glands. The cause etiology composition not totally clear; however composition lability and menopause are clindamycin phosphate gel composition factors.

CROSS-REFERENCE

The organism Demodex folliculorum is found frequently in the contents of inflamed pustular follicles, and has a possible role in this skin disorder. Treatments include topical metronidazole and oral tetracycline type clindamycin phosphate. One aspect of this invention click at this page a composition having a pH of about 3. The composition comprises a a therapeutically-effective amount of at least one compound useful for treating such disorder, b a pharnaceutically-acceptable polyacrylic acid polymer compatible with the compound, c optionally a water miscible composition, d optionally a preservative, e optionally an oil phase and surfactant, and composition water.

Another aspect of the invention is a composition described above in combination with a container that accurately administers a portion of the composition for topical administration to clindamycin phosphate gel patient.

Another aspect more info the invention is a composition described above in combination with labeling instructions for use in treating the skin disorder. Still another aspect of the invention is a method for treating a skin disorder in a human subject, which method comprises administering a composition described above to an affected area of the subject's skin having such disorder in an amount and for a period of time sufficient to improve the skin disorder.

Still another aspect of the invention is a method for preparing a clindamycin phosphate gel composition click this invention by combining water with a therapeutically-effective clindamycin phosphate gel composition composition a suitable compound and the polymer and optionally a water-miscible solvent and preservative.

If a lotion is desired an oil clindamycin phosphate gel composition is formed for clindamycin phosphate gel composition with the aqueous phase. Other aspects of the invention may be apparent composition further reading the specification and claims clindamycin phosphate gel composition the patent application.

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