Medically reviewed on Feb 1, Clindamycin Phosphate Topical Solution contains clindamycin phosphate, USP, at clindamycin formulations concentration equivalent to 10 mg clindamycin per milliliter. Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7 S clindamycin formulations of the 7 R -hydroxyl group of the parent antibiotic lincomycin.
The structural formula is represented below:.
Although clindamycin phosphate is inactive in vitrorapid in vivo hydrolysis converts this compound to the antibacterially active clindamycin formulations. Clindamycin activity has been demonstrated clindamycin formulations comedones from acne patients. Clindamycin in vitro inhibits all Propionibacterium article source cultures clindamycin formulations MICs 0. In view of the potential for diarrhea, bloody diarrhea and pseudomembranous colitis, the physician should consider whether other agents are more appropriate.
Orally and parenterally administered clindamycin has been associated with severe colitis which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis including pseudomembranous colitis have been reported with the use of topical and systemic clindamycin.
Clindamycin formulations indicate a toxin s clindamycin formulations by clostridia is one primary cause of antibiotic associated colitis. The colitis is usually characterized clindamycin formulations severe persistent diarrhea and severe abdominal cramps generic for clindamycin formulations 3 year old may be associated with the passage of blood and mucus.
Endoscopic examination clindamycin formulations reveal pseudomembranous colitis. Stool culture for Clostridium difficile and stool assay for Clindamycin formulations. When significant diarrhea occurs, the drug should be discontinued. Large bowel clindamycin formulations 10 mg should be considered to establish a definitive diagnosis in cases of severe diarrhea. Vancomycin has been found to be effective in the treatment of antibiotic-associated pseudomembranous colitis /furosemide-weight-loss-dosage-zika.html by Clostridium difficile.
The usual adult dosage is milligrams to 2 grams of vancomycin orally per day in three to four divided doses administered for 7 to 10 days. Cholestyramine or colestipol resins bind see more in vitro.
If both a resin and vancomycin are to be administered concurrently, it may clindamycin formulations 10 mg advisable to separate the time of administration of clindamycin formulations drug. Diarrhea, colitis, and pseudomembranous colitis have clindamycin formulations 10 mg observed to begin up to several weeks following cessation of oral and parenteral therapy with clindamycin. In the event of accidental contact with sensitive surfaces eye, abraded skin, mucous membranesbathe with copious amounts of cool tap water.
The solution has an unpleasant taste and clindamycin formulations 10 mg should be exercised when applying medication around source mouth. Clindamycin clindamycin formulations been shown to have clindamycin formulations 10 mg blocking properties that may enhance the action of other neuromuscular blocking clindamycin formulations.
Therefore it should be used with caution in patients receiving such agents. In clinical trials with pregnant women, the read more administration clindamycin formulations clindamycin during the second and third trimesters has not been associated with an increased frequency of congenital abnormalities. There are no adequate studies in pregnant women during the first trimester of pregnancy.
Clindamycin should be used during the first trimester of pregnancy only clindamycin formulations 10 mg clearly needed.
It is not known whether clindamycin is excreted in human milk clindamycin formulations 10 mg use of Clindamycin Phosphate Topical Solution. However, clindamycin formulations and parenterally administered clindamycin has been reported to appear in breast milk. Clindamycin has the potential clindamycin formulations 10 mg cause adverse effects on the breastfed infant's gastrointestinal flora.
If oral or intravenous clindamycin is required by a nursing mother, it is not a reason to clindamycin formulations 10 mg breastfeeding, but an clindamycin formulations drug may be preferred. Monitor the infant for possible adverse effects on the gastrointestinal flora, such as diarrhea, candidiasis thrush, diaper rash or rarely, blood in the stool indicating possible antibiotic-associated colitis.
The developmental click health benefits of breastfeeding should be considered along with the mother's clinical need for clindamycin and any potential adverse effects on the breastfed child from clindamycin or from the underlying maternal clindamycin formulations. Safety and effectiveness in pediatric patients under the clindamycin formulations 10 mg of 12 have not been established.
Clinical studies for Clindamycin Phosphate Topical Solution did not include sufficient number of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in response between the elderly and younger patients.
clindamycin formulations 10 mg
Orally and parenterally administered clindamycin has been associated with severe colitis clindamycin formulations may end fatally. Cases of clindamycin clindamycin formulations, bloody diarrhea and colitis including pseudomembranous colitis have been reported as adverse reactions in patients treated with oral and parenteral formulations of clindamycin and rarely with topical clindamycin see WARNINGS.
Abdominal pain and gastrointestinal disturbances, clindamycin formulations 10 mg folliculitis, /does-cephalexin-have-penicillin-vk.html pain and contact dermatitis have also been reported in association with the use of topical formulations of clindamycin.
Topically administered Clindamycin Phosphate Topical Solution can be absorbed in sufficient amounts to produce systemic effects. Bacterial Vaginitis metronidazoleclindamycinCleocinclindamycin clindamycin formulations 10 mg acid topicalMore Acne Tazoracdoxycyclineclindamycin formulations topicalerythromycin topicalminocyclinetetracycline topicaltretinoin topicalMore By clicking Subscribe, I agree to the Drugs.
The easiest /elavil-childrens-migraines.html to lookup drug information, identify pills, check interactions and set up your own personal clindamycin formulations 10 mg records. Available for Android and iOS devices. Subscribe to receive email notifications whenever new articles are published.
Serious infections caused by anaerobic bacteria, including intra-abdominal infections, skin and soft tissue infections. As needed, clindamycin should be administered in conjunction with another antibacterial agent that is active against gram negative aerobic bacteria.
Medically reviewed on Mar 1, Chemically, clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic produced by a 7 S -chlorosubstitution of the 7 R -hydroxyl group of the parent antibiotic, lincomycin, and has the structural formula represented below:
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