To evaluate the efficacy and safety of fluticasone proprionate aqueous nasal spray in children aged 4 to 11 years with seasonal allergic rhinitis.
Multicenter, randomized, double-blind, placebo-controlled, parallel-group. Two hundred fifty children aged 4 to 11 years with moderate-to-severe nasal symptoms, a positive skin test reaction to a late-summer or autumn allergen, a history of seasonal allergic rhinitis, and documentation of an unsatisfactory response to conventional treatment.
Children were randomly assigned to receive fluticasone propionate, either micrograms /keppra-for-nerve-pain-quit-smoking.html micrograms, or placebo, given by intranasal spray once daily in the morning for 14 days.
Severity of nasal symptoms obstruction, rhinorrhea, itching, and can i take flonase everyday propionate nasal spray was recorded on visual analog scales by investigators at weekly visits and by patients or adult guardian daily in the evening.
There were no significant differences between the two fluticasone propionate dosages in any efficacy measurement. Morning plasma cortisol concentrations and frequency of drug-related adverse events were similar in the fluticasone propionate can placebo take flonase everyday. In children as young as 4 years, micrograms propionate nasal spray fluticasone propionate aqueous nasal spray given once daily is as effective can i take flonase everyday propionate nasal spray micrograms given once daily, the usual adult dose can i take flonase everyday propionate nasal spray the treatment of seasonal allergic rhinitis.
Both fluticasone propionate dosages were well tolerated and neither dosage appears to interfere with the hypothalamic-pituitary-adrenal axis in children.
Intranasal steroid sprays are safe for long-term use, and there is little evidence to indicate they cause significant systemic side effects. However, patients with chronic rhinitis who might use them for long periods should be advised to use them only intermittently and at the lowest dose that controls their symptoms. Patients who regularly use steroid sprays should undergo examination of the nasal cavity at least annually to check for damage to the septum.
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